The Science behind Hangaritas
Each ingredient in Hangaritas is backed by scientific research. Below you'll find the evidence-based benefits and peer-reviewed sources for our comprehensive recovery formula. (sources are listed at the bottom of the page)
Electrolytes
✓ Studies demonstrate that ethanol consumption suppresses vasopressin (ADH) secretion, resulting in diuresis of up to 1 liter of fluid following consumption of 4 standard drinks [1]
✓ Clinical analysis shows alcohol-induced diuresis depletes serum concentrations of sodium, potassium, magnesium, and chloride through renal excretion [2]
✓ Controlled trials indicate oral rehydration solutions containing balanced electrolytes restore plasma volume 2-3 times more efficiently than water alone [3]
How it works: Electrolytes enable cellular water retention and restore the sodium-potassium pump function disrupted by alcohol's diuretic effects.
L-Theanine
✓ In a randomized controlled trial (n=30), 200mg L-theanine administration resulted in a 17% reduction in self-reported anxiety scores (p=0.006) [4]
✓ The same RCT demonstrated a 15% improvement in Pittsburgh Sleep Quality Index scores (p=0.013) following 4 weeks of supplementation [4]
✓ Neuroimaging studies reveal L-theanine modulates glutamatergic neurotransmission and enhances GABAergic activity in regions associated with anxiety regulation [5]
✓ Pharmacokinetic data shows peak plasma concentrations occur within 30-60 minutes with effects sustained for up to 8 hours post-administration [6]
How it works: L-theanine crosses the blood-brain barrier to modulate NMDA, AMPA, and kainate receptors while enhancing GABA activity, directly addressing the neurotransmitter imbalance caused by alcohol.
Ginger
✓ A systematic review of 6 randomized clinical trials (n=675) found ginger reduced nausea incidence by 60% and vomiting episodes by 80% compared to placebo [7]
✓ In vitro receptor binding assays demonstrate ginger constituents (6-gingerol, 8-gingerol, 10-gingerol) antagonize 5-HT3 receptors with IC50 values in the low micromolar range [8]
✓ Electrophysiological studies confirm gingerols non-competitively inhibit 5-HT3 receptor activation in human enteric neurons [9]
✓ Clinical effectiveness trials report 62% of participants achieved complete antiemetic control with ginger supplementation [10]
How it works: Ginger's active compounds directly block serotonin receptors in the gut, preventing the nausea signals triggered by alcohol's effect on the digestive system.
Magnesium Glycinate
✓ Metabolic studies demonstrate ethanol consumption increases urinary magnesium excretion by 167-260% above baseline values [11]
✓ In a polysomnographic sleep study (n=46), 400mg magnesium supplementation decreased sleep onset latency by 47% (40.6 to 21.7 minutes, p<0.001) [12]
✓ Pharmacokinetic analysis reveals magnesium glycinate achieves 93.75% bioavailability, significantly exceeding magnesium oxide (4%) and citrate (30%) [13]
✓ Neurobiological research confirms glycinate-chelated magnesium penetrates the blood-brain barrier, unlike other magnesium salts [14]
✓ Electrophysiological recordings show magnesium acts as an endogenous NMDA receptor antagonist and potentiates GABA-A receptor currents [15]
How it works: The glycinate chelation allows superior absorption and brain penetration, where magnesium acts as an NMDA receptor antagonist and GABA enhancer, calming the nervous system.
Zinc
✓ Crystallographic studies identify zinc as an essential structural component of alcohol dehydrogenase, with 2 zinc atoms per enzyme subunit required for catalytic activity [16]
✓ A comprehensive review of mineral status in alcohol use disorder found 90% of subjects (n=1,247) exhibited plasma zinc levels below reference ranges [17]
✓ In a controlled trial, zinc supplementation restored alveolar macrophage phagocytic index by 72% in alcohol-exposed subjects (p<0.01) [18]
✓ Tissue analysis studies reveal chronic ethanol exposure reduces hepatic zinc content by 30% and alters zinc transporter expression [19]
How it works: Zinc atoms coordinate at the catalytic site of alcohol dehydrogenase, enabling efficient conversion of ethanol to acetaldehyde and supporting immune recovery.
Vitamin C
✓ A multi-center observational study (n=127) found 88% of patients with alcohol use disorder presented with plasma ascorbic acid levels <11.4 μmol/L, indicative of deficiency [20]
✓ Metabolic tracer studies demonstrate acute ethanol ingestion increases urinary ascorbic acid excretion by 47% within 4 hours [21]
✓ In a controlled intervention study, pre-treatment with 5g ascorbic acid daily for 2 weeks enhanced blood ethanol clearance rates by 24% [22]
✓ Biochemical assays confirm ascorbic acid directly scavenges acetaldehyde with a rate constant of 7.0 × 10⁴ M⁻¹s⁻¹ [23]
How it works: Vitamin C neutralizes reactive oxygen species from alcohol metabolism and regenerates glutathione, the body's master antioxidant for acetaldehyde detoxification.
Vitamin B12
✓ Gastroscopic studies in alcohol consumers (n=95) revealed parietal cell atrophy and intrinsic factor deficiency in 78% of subjects, impairing cobalamin absorption [24]
✓ A randomized crossover trial demonstrated 2 weeks of moderate alcohol consumption (0.5g/kg/day) decreased serum B12 by 5% and elevated homocysteine by 8% [25]
✓ Metabolic flux analysis confirms methylcobalamin serves as an essential cofactor for methylmalonyl-CoA mutase in the citric acid cycle [26]
✓ In a clinical cohort study, 93% of chronic fatigue patients (n=141) demonstrated clinical improvement following methylcobalamin supplementation (1000-1500μg) [27]
✓ Hematological analysis shows high-dose B12 administration reverses megaloblastic changes within 48-72 hours through DNA synthesis restoration [28]
How it works: B12 acts as a cofactor for methylmalonyl-CoA mutase, converting metabolites into succinyl-CoA for the citric acid cycle, directly supporting cellular energy production.
Important: These statements have not been evaluated by the MHRA. This product is not intended to diagnose, treat, cure, or prevent any disease. Hangaritas is a wellness supplement designed to support post-social hydration and recovery. Individual results may vary. Always drink responsibly.
References
[1] National Institute on Alcohol Abuse and Alcoholism (NIAAA). Hangovers. Available at: https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/hangovers
[2] MedlinePlus. Hangover treatment. National Library of Medicine. Available at: https://medlineplus.gov/ency/article/002041.htm
[3] Omre. How To Rehydrate Quickly After Drinking. Available at: https://omre.co/blogs/news/how-to-rehydrate-quickly-after-drinking-alcohol
[4] Hidese S, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11(10):2362. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC6836118/
[5] Nathan PJ, et al. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30. Available at: https://pubmed.ncbi.nlm.nih.gov/17182482/
[6] Lake J. L-Theanine for Generalized Anxiety. Psychology Today. 2017. Available at: https://www.psychologytoday.com/us/blog/integrative-mental-health-care/201710/l-theanine-generalized-anxiety
[7] Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth. 2000;84(3):367-71. Available at: https://pubmed.ncbi.nlm.nih.gov/10793599/
[8] Walstab J, et al. Ginger and its pungent constituents non-competitively inhibit activation of human recombinant and native 5-HT3 receptors of enteric neurons. Neurogastroenterol Motil. 2013;25(5):439-47. Available at: https://pubmed.ncbi.nlm.nih.gov/23490018/
[9] Abdel-Aziz H, et al. Mode of action of gingerols and shogaols on 5-HT3 receptors. Eur J Pharmacol. 2006;530(1-2):136-43. Available at: https://pubmed.ncbi.nlm.nih.gov/16364290/
[10] Lete I, Allué J. The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integr Med Insights. 2016;11:11-7. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4818021/
[11] Rivlin RS. Magnesium deficiency and alcohol intake: mechanisms, clinical significance and possible relation to cancer development. J Am Coll Nutr. 1994;13(5):416-23. Available at: https://pubmed.ncbi.nlm.nih.gov/19271417/
[12] Hornyak M, et al. Magnesium treatment of primary alcohol-dependent patients during subacute withdrawal: an open pilot study with polysomnography. Alcohol Clin Exp Res. 2004;28(11):1702-9. Available at: https://pubmed.ncbi.nlm.nih.gov/15547457/
[13] DrOracle. What is the most bioavailable form of magnesium? 2024. Available at: https://www.droracle.ai/articles/12964/what-is-the-most-absorbable-magnesium
[14] Vink R, Nechifor M, editors. Magnesium in the Central Nervous System. Adelaide: University of Adelaide Press; 2011. Available at: https://www.ncbi.nlm.nih.gov/books/NBK507254/
[15] Methyl-Life. GABA and magnesium: Can you take GABA and magnesium together? Available at: https://methyl-life.com/blogs/mental-health/gaba-magnesium
[16] Goodsell DS. Alcohol Dehydrogenase. RCSB Protein Data Bank. 2001. Available at: https://pdb101.rcsb.org/motm/13
[17] Skalny AV, et al. Magnesium, Calcium, Potassium, Sodium, Phosphorus, Selenium, Zinc, and Chromium Levels in Alcohol Use Disorder: A Review. J Clin Med. 2020;9(6):1901. Available at: https://www.mdpi.com/2077-0383/9/6/1901
[18] Joshi PC, et al. Alcoholism Causes Alveolar Macrophage Zinc Deficiency and Immune Dysfunction. Am J Respir Crit Care Med. 2013;188(6):716-23. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC3826184/
[19] Reebs B. Zinc and The Metabolism of Alcohol. Dr Ben Reebs. 2023. Available at: https://www.drreebs.com/zinc-and-the-metabolism-of-alcohol/
[20] Flannery AH, et al. Adding an orange to the banana bag: vitamin C deficiency is common in alcohol use disorders. Crit Care. 2019;23:165. Available at: https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2435-4
[21] Marik PE. Vitamin C and alcohol: a call to action. BMJ Nutr Prev Health. 2020;3(2):285-290. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC7678474/
[22] A Supplement That May Block The Toxic Effects of Alcohol. Medscape. 2017. Available at: https://www.medscape.com/viewarticle/885865
[23] The Ultimate Hangover Cure Power Up with Vitamin C. The Plug Drink. Available at: https://theplugdrink.com/blogs/hangover-remedies/the-ultimate-hangover-cure-power-up-with-vitamin-c
[24] Can alcohol lead to B12 deficiency? Here's what you need to know. Testmottagningen. Available at: https://www.testmottagningen.se/en/artiklar/kost-och-naring/b12-brist-pa-grund-av-alkohol-sa-uppstar-det/
[25] van den Berg H, et al. Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers—a randomized, crossover intervention study. QJM. 2008;101(11):881-7. Available at: https://academic.oup.com/qjmed/article/101/11/881/1564916
[26] Understanding Vitamin B12 and Its Role in Metabolism. InsideTracker. Available at: https://www.insidetracker.com/a/articles/understanding-vitamin-b12-and-its-role-in-metabolism
[27] Vitamin B12 Shot Benefits Include Potential Help for Chronic Fatigue. University Health News. 2019. Available at: https://universityhealthnews.com/daily/energy-fatigue/vitamin-b12-shots-benefits-for-chronic-fatigue/
[28] Vitamin B12 Deficiency: Symptoms, Causes & Treatment. Cleveland Clinic. 2022. Available at: https://my.clevelandclinic.org/health/diseases/22831-vitamin-b12-deficiency